How gender-affirming care can affect your fertility
Different gender-affirming medical interventions can affect fertility in different ways. In many cases, these effects depend on how long treatment continues and whether it is stopped later. Research is still developing, but the following overview reflects what clinicians currently understand.
Puberty blockers (GnRH agonists)
Timing is a key factor for younger individuals. Puberty blockers pause physical development, which may prevent the body from reaching the stage at which eggs or sperm can be produced and stored. For transgender individuals who have already gone through puberty, puberty blockers are typically regarded as reversible.
In these cases, the puberty blocker works by suppressing the body’s hormone production, supporting the use of gender-affirming hormones rather than pausing the pubertal process.
Anti-androgens
Anti-androgens reduce the effects of testosterone in the body. They can suppress sperm production and erections, though fertility may sometimes return if treatment is stopped.
Oestrogen
Oestrogen therapy suppresses sperm production. Fertility may recover if treatment stops, but this does not happen in every case. See this 2023 international study on trans women’s fertility preservation for more information.
Testosterone
Testosterone can reduce egg production and overall fertility. However, some transmasculine people have paused testosterone in order to conceive. (See the Trans Pregnancy Project for more information.)
It’s also important to know that testosterone is not a contraceptive. If you are taking testosterone and have a uterus and ovaries, pregnancy is still possible. Because testosterone can harm a developing foetus, anyone having sex that could result in pregnancy should use effective contraception if they do not want to conceive. A healthcare provider can help you find contraception options that work for your body and circumstances.
The WPATH Standards of Care (Version 8, Chapter 16) provides current guidance on reproductive health, fertility preservation, pregnancy, contraception, and related care for gender-diverse people.