This guidance is the result of political decisions, not new clinical evidence
The decisions that have led to today’s guidance (the Cass Review, the ban on puberty blockers, the pause on hormone treatment for 16 and 17-year-olds, and the pause and cancellation of the Pathways trial) share something in common. None of them arose from a sudden body of new evidence. All of them arose from a political environment in which trans+ people have been made a target, and in which those in power have applied a standard of proof to trans+ healthcare that is not applied to any comparable area of medicine.
The MHRA official who triggered the pause of the Pathways trial had a documented history of anti-trans posts on social media. The independent review into exogenous hormones used methodological approaches, including a 97% exclusion rate for relevant studies, which leading research methodologists have described as “egregious and unconscionable.”
The same treatments that the NHS now claims lack sufficient evidence have been used safely for decades, and the evidence for them includes a study of 315 participants published in the New England Journal of Medicine, finding significant reductions in depression and suicidality.
When politics shapes clinical decisions, patients are harmed. Trans+ young people in the UK are being harmed, right now, by these decisions. I will not be complicit in describing that harm as a neutral, evidence-based process.