The PATHWAYS trial: limited access, with conditions
In the UK, the PATHWAYS trial is currently the only legal way for trans+ young people to access puberty blockers through UK-based prescribers. However, many trans+ people, parents and health experts have expressed concern that that’s not the answer it’s made out to be. The trial is limited to a tiny sample of 226 young people, while more than 6,000 are currently sitting on waiting lists.
Most families will never be offered a place, and even if they are accepted to the trial, a place is not a promise of treatment. Young people are randomly split into two groups. One starts puberty blockers straight away, whilst the other waits a year before being able to start the medication. That means a young person can go through the whole process and still wait, while puberty carries on.
On top of this, young people face more than 13 hours of assessments and around 50 forms, including questions on trauma and suicide, before treatment. This is an extremely heavy process to ask of a child, and of the parents beside them, even more so when bearing in mind that half the trial participants will still not be able to access puberty blockers for a year.
A troubled start and concerns about consent
The trial itself has had a troubled start: it was paused in February 2026 after the medicines regulator, the Medicines and Healthcare products Regulatory Agency (MHRA), raised safety concerns, then allowed to resume with a new minimum age of 11 or 12 depending on sex registered at birth, and only began recruiting in August after the High Court threw out a legal challenge.
Three leading trans health organisations, the European, World and US Professional Associations for Transgender Health, have warned that some families may feel forced to join because there is no other route to gain access for their child expressing signs of distress, expressing concern that this puts research goals ahead of young people’s wellbeing.
Despite these criticisms, the UK government says the trial passed strict scientific and ethical checks. Dr Hilary Cass, who led the controversial UK review, has also defended the trial, saying more children will be harmed without it.